Research Interest

Dr Shumaila Aman has completed her PhD in Pharmacology from Dr Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, and is associated with DUHS as Assistant Professor of Pharmacology in Dow College of Pharmacy since 2015. After her PhD, she was recommended by Higher Education Commission of Pakistan (HEC) for interim placement at Dow University of Health Sciences (DUHS), Karachi, Pakistan as an Assistant Professor of Pharmacology. After successful completion of her HEC interim tenure and achieving the HEC Research grant she has been appointed as regular faculty at DUHS. During her stay at DUHS she was awarded the Chinese Government scholarship and went for her Postdoctoral Research degree from TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Drug Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China. During her stay in China, other than her novel research, she also worked as a visiting faculty in a Medical and Pharmacy College and participated as a speaker in international conferences in China.
From 2015 to date at DUHS, her success stories include securing HEC research grant, Chinese govt scholarship, supervision of an MPhil student and multiple ongoing research projects. Her research focuses on pharmacology of inflammation, platelet aggregation, and thrombosis and signal transduction during aggregation, and complications of cardiovascular diseases. During her doctorate, she worked on antioxidant, antiplatelet and phosphodiesterase inhibitory potential of different drugs, developed the assay for antiplatelet activity, and monitoring the release of ATP during platelet aggregation. During her post-doctorate, she has research experience involving cancers understanding at molecular level, complications of inflammation during cancers, molecular mechanisms as well as molecular and environmental impact over it.

Research Publications

1. Tasneem, S., Yang, Y., Liu, B. Muhammad Iqbal Choudhary, Wei Wang (2021). Cytotoxicity of Schisandronic Acid from Kadsura coccinea by Activation of Caspase-3, Cleavage of poly-ADP Ribose Polymerase, and Reduction of Oxidative Stress. Rev. Bras. Farmacogn. https://doi.org/10.1007/s43450-021-00136-7
2. Yu, H., Qiu, Y., Tasneem, S., Daniyal, M., Li, B., CAI, X., Atta-Ur Rahman, & Wang, W. (2021). Advancement of Natural Compounds as Anti- Rheumatoid Arthritis Agents: Focus on Their Mechanism of Actions. Mini reviews in medicinal chemistry, 10.2174/1389557521666210304112916. Advance online publication. https://doi.org/10.2174/1389557521666210304112916
3. Yu-pei Yang, Nusrat Hussain, Liu Zhang, Yan-zhe Jia, Yu-qing Jian, Bin Li, Muhammad Iqbal Choudhary, Atta-ur Rahman, Wei Wang, (2020) Kadsura coccinea: A rich source of structurally diverse and biologically important compounds. Chinese Herbal Medicines, 12(3): 214-223, https://doi.org/10.1016/j.chmed.2020.03.006.
4. Yang, Yu-Pei, Shumaila Tasneem, Muhammad Daniyal, Liu Zhang, Yan-Zhe Jia, Yu-Qing Jian, Bin Li, and Wei Wang. (2020). Lanostane tetracyclic triterpenoids as important sources for anti-inflammatory drug discovery. World J Tradit Chin Med [Epub ahead of print] [cited 2020 Sep 10]. Available from: http://www.wjtcm.net/preprintarticle.asp?id=290076
5. Tasneem, Shumaila, Muhammad Saleem, and Sheikh Arshad Saeed. (2020). Nonsteroidal anti-inflammatory drugs as potential ecto-nucleotide phosphodiesterase inhibitors. Brazilian Journal of Pharmaceutical Sciences, 56. DOI: 10.1590/s2175-97902019000318271
6. Yu, H.H., Lin, Y., Zeng, R., Li, X., Zhang, T., Tasneem, S., Chen, C., Qiu, Y.X., Li, B., Liao, J. and Wang, Y.H., (2019). Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb. Journal of ethnopharmacology, p.111902. DOI: 10.1016/j.jep.2019.111902
7. Liang Cao, Nuzhat Shehla, Shumaila Tasneem, Mengru Cao, Wenbing Sheng, Yuqing Jian, Bin Li, Caiyun Peng, M. Iqbal Choudhary, Atta-ur Rahman, Duanfang Liao, Wei Wang. (2019). New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita. Molecules 2019, 24(9), 1664. DOI: 10.3390/molecules24091664
8. Huang-he, Y., Zeng, R., Lin, Y., Li, X., Tasneem, S., Yang, Z., Qiu, Y.X., Li, B., Wang, Y.H., Cai, X. and Wang, W. (2019). Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats. Phytomedicine, p.152876. DOI: 10.1016/j.phymed.2019.152876
9. Tasneem, S., Liu, B., Li, B., Choudhary, M. I., & Wang, W. (2018). Molecular pharmacology of inflammation: medicinal plants as anti-inflammatory agents. Pharmacological research 3; 139:126-140. DOI: 10.1016/j.phrs.2018.11.001. Jan 2019
10. Zeng, T., Tang, Y.R., Li, B., Tasneem, S., Yuan, H.W., Jia, Y.Z., Daniyal, M., Hussain, N., Wang, W.M., Zuo, D.L. and Gong, L.M., (2018). Chemical characterization of constituents from Polygonatum cyrtonema Hua and their cytotoxic and antioxidant evaluation. Natural product research, DOI: 10.1080/14786419.2018.1543682
11. Yongbei Liu, Yupei Yang, Shumaila Tasneem, Nusrat Hussain, Muhammad Daniyal, Hanwen Yuan, Qingling Xie, Bin Liu, Jing Sun, Yuqing Jian, Bin Li, Shenghuang Chen and Wei Wang. (2018). Lignans from Tujia Ethnomedicine Heilaohu: Chemical Characterization and Evaluation of Their Cytotoxicity and Antioxidant Activities, Molecules, 23(9), 2147. DOI: 10.3390/molecules23092147. Aug 2018
12. Aman Shumaila, Hina Tabassum, and Sumbul Shamim. "Safety from the Adverse Effects of Cyclooxygenase-2 Inhibitors during Pain and Inflammation, and Platelet Aggregation by Utilizing NADPH Oxidase Inhibitors. (2017). Journal of Pharmacological and Toxicological Methods 88: 234-235. DOI: 10.1016/j.vascn.2017.09.217 [international conference abstract] Dec 2017
13. Saeed, SA, Khan, NS, Saleem, A, Qureshi, Z-U-R, Saeed, TZ, Quadri, J, Tasneem, S, and Waqar, MA. (2009). Role of cytokines in the pathophysiology of hypertension during preeclampsia. Journal of the Chemical Society of Pakistan, 31(1): 175-185
14. Saeed, SA, Connor, JD, Quadri, J, Tasneem, S, Ahmed, S, Mesaik, MA, and Choudhary, MI. (2007). Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation. Pharmacological Reports, 59(2): 238. https://www.ncbi.nlm.nih.gov/pubmed /17556803
15. Saeed, SA, Mesaik, MA, Quadri, J, Tasneem, S, Motiwala, A, Khalid, U, AH, SU, Hussain, F, and Choudhary, MI. (2006). Interactions of cyclooxygenase inhibitors with reactive oxygen species. Journal of Pharmacology and Toxicology, 1(2): 115-125. DOI: http://10.3923/jpt.2006.115.125
16. Saeed, SA, Manzoor, I, Quadri, J, Tasneem, S, and Simjee, SU. (2005). demystifying phytochemicals: an insight. International Journal of Pharmacology, 1(3): 234-238. DOI: 10.3923/ijp.2005.234.238.
17. Saeed, S, Tasneem, S, Qidwai, N, and Simjee, S. (2005). Low dose aspirin depresses human platelet aggregation triggered by activating agents whose mechanisms involve arachidonic acid. Journal of the College of Physicians and Surgeons--Pakistan, 15(10): 665. https://www.ncbi.nlm.nih.gov/pubmed/19810316.

Others

HEC Approved Supervisor
International Conference at 4th Hunan biomedical-traditional Chinese medicine international innovation forum, TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Drug Research Institute, School of Pharmacy, Hunan University of Chinese Medicine Changsha, Hunan, China Oct 2018
International Conference at Safety Pharmacology society, Japanese safety pharmacology society and Canadian Society of pharmacology and therapeutics Joint meeting Vancouver, Canada Sep 2016