Research Interest

Conducting extensive research work with fifteen years of research Experience. Ph.D. degree and 24 research articles are published in well-reputed international journals. One of the research projects has been accepted by the Higher Education Commission (HEC) of Pakistan under the IPFP Program of HEC & being completed subsequently. 

Number of research articles reviewed for different scientific journals 

•                              Journal of King Saud University, Sciences,

•                              Molecules, MDPI.

•                              Pakistan Journal of Pharmaceutical sciences

•                              Member of AS Pharmacology Journal.

Design and synthesis of new bio-active molecules using computer-aided modeling techniques and organic synthesis mechanisms.

•                              RP-HPLC method development and Drug-Drug interaction studies.

•                              Spectroscopic degradation method development and identification of degradation products.

•                              In-vitro Antimicrobial, Anti-fungal, Anti-urease, Radical scavenging, Anti-inflammatory, and Anti-diabetic activities.

•                              Metal Complexes Synthesis and Characterization.

•                              Modeling of small organic molecules, proteins, and protein-ligand interactions.

•                              Ligand-based and structure-based pharmacophore design.

•                              Generation and screening of large virtual combinatorial compound libraries • Molecular activity determination using 3D-QSAR or quantum chemistry calculations and DFT Studies.

•                              Molecular Dynamics (MD) simulations studies of protein-ligand complex Proficiencies: -

1. Preliminary understanding of computational chemistry theory, and very proficient in the operation of most computational chemistry software.
    
2.  Detailed knowledge of computer operating systems including UNIX, Linux, and Windows, Installation, maintenance, and repair. All major word processing, presentation, and database manipulation software packages.
    
3. Experience in Medicinal Chemistry packages including Autodock, Pyrex, Maestro, Autodock vina, Gaussian, GaussView, CS Chem Office, software compilation, desktop publishing, and hardware assembly.
    
4. Detailed knowledge of almost all organic laboratory equipment, especially Uv-Visible Spectrophotometer, NMR, FT-IR, GC, GC-MS, LC-MS, HPLC (analytical and prep), chromatography, photochemical apparatus, low temperatures, inert atmospheres.
    
5. Isolation, degradation, and derivatization of Organic Compounds. Structure elucidation with modern NMR techniques.
    
6. Use of current analytical and predictive tools including HPLC, GCMS, LCMS and Counter current chromatography.
    
7. Proficient with the operation, maintenance, and small repairs of technical and sensitive lab equipment (HPLC pumps, rotary chromatograms, vacuum apparatus).
    
8. Success as a laboratory and tutorial instructor in general and organic chemistry, Experienced working in a multidisciplinary team.
    
9. Appropriate organization, record keeping, and verbal and written communication skills.
    
10. A motivational leader with excellence in recruiting, training, and developing exceptional people, driving change, and meeting challenges. Research expertise lies in field of RP-HPLC Method Development and Validation, Co-ordination chemistry, Organic synthesis, Kinetic studies, Spectroscopic techniques, in-vitro-Interaction studies and Antimicrobial assays.
     

Research Publications

 1.    Muhammad Moazzam Bin Rasheed , Marvah Mehmood Rana , Marvah Mehmood Rana , Mian Talha Sarfraz , Sana Shamim , Irshad Begum , Safia Khan , Dr. Noor Jahan , Muhammad Hassan Taj , Muhammad Adil Aziz. (2023). Metagenomic Analysis Of Human Gut Microbiota. Journal of Pharmaceutical Negative Results, 651–670. https://doi.org/10.47750/pnr.2023.14.04.78

2.    Muhammad Moazzam Bin Rasheed , Mian Talha Sarfraz , Marvah Mehmood Rana , Muhammad Hassan Taj , Sana Shamim , Sadaf Ibrahim , Noor Jahan , Muhammad Ameer Moaavia. (2023). Molecular Interaction Of Acetyl-Coa Carboxylase (Accase) With Fenoxaprop-P Ethyl Through Computational Analysis. Journal of Pharmaceutical Negative Results, 544–559. Retrieved from https://www.pnrjournal.com/index.php/home/article/view/10469

3.    .Gemifloxacin-transition metal complexes as therapeutic candidates: antimicrobial, antifungal, anti-enzymatic, and docking studies of newly synthesized complexes, Shamim S, Gul S, Rauf A, Rashid U, Khan A, Amin R, Akhtar F, 8(8)2022, e10378. https://doi.org/10.1016/j.heliyon.2022.e10378

4.     A Combinatorial Approach towards Antibacterial and Antioxidant Activity Using Tartaric Acid Capped Silver Nanoparticles. . Begum, I.; Shamim, S.; Ameen, F.; Hussain, Z.; Bhat, S.A.; Qadri, T.; Hussain, M. Processes 2022, 10, 716. https://doi.org/10.3390/ pr10040716

5.     Biological & Enzymatic profiling of newly synthesized heavy metal complexes of Gemifloxacin, Sana shamim, Somia Gul, Ajmal Khan, Ateka Ahmed and Afeefa Gul, Pharmaceutical Chemistry Journal (2022) 55(4)DOI: 10.1007/s11094-021-02534-6 Pharmaceutical Chemistry Journal 2022.

6.     New series of hydrazinyl thiazole derivatives of piperidin-4-one: Synthesis, structural elucidation, analgesic activity and comparative structure activity relationship Rubina Siddiqui, Shamim Akhtar , Shazia Haider , Zafar Saied Saify , Mahwish Akhtar, Sana Shamim. doi.org/10.36721/PJPS.2021.34.4.REG.1415-1420.1 Pak. J. Pharm. Sci., Vol.34, No.4, July 2021, pp.1415-1420 1415.

7.     Antibacterial, antifungal and enzymatic activities of azithromycin heavy metal complexes: newly synthesized and characterized. Sana Shamim, Irshad Begum, Wajiha Gul, Tehseen Quds, Muhammad Imran, Erum Shah, Noor Jahan. Pakistan journal of pharmaceutical sciences. (2021) doi.org/10.36721/PJPS.2021.34.3.SUP.1149-1156.1

8.     Facile Fabrication of Malonic Acid Capped Silver Nanoparticles and Their Antibacterial Activity, Irshad Begum, Fuad Ameen, Zahid Soomro , Sana Shamim , Saleh AlNadhari, A. Almansob , Ahmed Al-Sabri, Afsheen Arif. Journal of King Saud University - Science 33 (2021) 101231. https://doi.org/10.1016/j.jksus.2020.101231.

9.     Simultaneous determination of moxifloxacin with non-steroidal anti-inflammatory drugs (NSAIDs) in bulk, dosage formulations and serum by RP-HPLC: application to in-vitro drug interactions, Akhtar, Mahwish; Shamim, Sana; Sultana, Najma; Arayne, Saeed Gul, Somia; PJPS (2021), 34 (6), p2091-2099. 9p. doi.org/10.36721/PJPS.2021.34.6.REG.2091-2099.1

10.     Synthesis, characterization, in-vitro bacterial, fungal and enzymatic activities of C-7 modified gemifloxacin analogues, Sana Shamim, Somia Gul, Mahwish Akhtar, Ajmal Khan, Irshad Niazi, Huda Ashraf. IJBPAS, June 2021, 10(6): 1733-1745.

11.     Cost-effective Analysis of Proton Pump Inhibitors in Long-term Management of Gastroesophageal Reflux Disease: A Narrative Review Shazia Jamshed, Akshaya Srikanth Bhagavathula, Sheikh Muhammad Zeeshan Qadar, Umaira Alauddin, Sana Shamim, Sohail Hasan , hospital pharmacy, 2019, https://doi.org/10.1177/0018578719893378

12.    . Synthesis and antimicrobial evaluation of unique 3- carboxamide derivatives of moxifloxacin with selected H2 inhibitor Mahwish akhtar , Sana Shamim, Tanveer Ahmed Siddiqi , Najma Sultana and M. S. Aarayne International journal of biology, pharmacy and applied sciences, 2019, 8(5): 968- 980. https://doi.org/10.31032/IJBPAS/2019/8.5.4709

13.     RP-HPLC method for the simultaneous estimation of lisinopril and diuretics in bulk, dosage forms and human serum. Rubina Muzaffar, Sana Shamim, Najma Sultana., M. S Arayne and Mahwish Akhtar. International journal of biology, pharmacy and applied sciences, 2018, 7(12): 2005-2016.https://doi.org/10.31032/IJBPAS/2018/7.12.4593

14.     Synthesis, characterization and Antimicrobial Activities ofzithromycin Metal Complexes of. Najma Sultana, M.S. Arayne, Sana Shamim and Asia Naz. Modern Chemistry and Application..2014 IF: 1.55

15.     Synthesis, Characterization, Antibacterial and Antifungal Studies of Azithromycin with NSAIDS, Sana Shamim, Najma Sultana and M Saeed Arayne, 2013.

16.     Sparfloxacin-Metal Complexes as Urease Inhibitors: their Synthesis, Characterization, Antimicrobial and Anti-Enzymatic Evaluation S Gul, N Sultana, M. S Arayne, Sana Shamim, Mahwish Akhtar and A Khan (2013), journal of chemistry, Vol 2013, 12.

17.     New Method for Optimization and Simultaneous Determination of Sparfloxacin and Non-Steroidal Anti-Inflammatory Drugs: Its In-Vitro Application Somia Gul, Najma Sultana, Muhammad Saeed Arayne, Sana Shamim, Mahwish Akhtar, 2012., American Journal of Analytical Chemistry, 3, 328-337, IF: 1.46  

18.     Sparfloxacin determination in bulk materials, pharmaceutical formulations and human serum by reverse phase HPLC method, African Journal of Pharmacy and Pharmacology, Somia Gul, Najma Sultana, M. Saeed Arayne, Sana Shamim and Mahwish Akhtar, 2013.

19.     Validated Method for the Simultaneous Determination of Gemifloxacin and H2-receptor antagonists in Bulk, Pharmaceutical Formulations and Human Serum by RP-HPLC; In-vitro Applications.  Najma Sultana, M. Saeed Arayne, Sana Shamim and Asia Naz. Journal of Chinese Chemical Society, Published on line 25th May, 2011.

20.      Validated Method for the Determination of Gemifloxacin in Bulk, Pharmaceutical Formulations and Human Serum by RP-HPLC: In Vitro Applications, Najma Sultana, M. Saeed Arayne, Sana Shamim*, Mahwish Akhtar and Somia Gul. Journal of Brazilian Chemical Society, 2011, vol. 22, 987. IF: 1.46

21.    Simultaneous Determination of Moxifloxacin and H2 receptor antagonist in Pharmaceutical Dosage Formulations By RP-HPLC: application to in-vitro drug interactions, Najma Sultana, M. Saeed Arayne, Mahwish Akhtar, Sana Shamim*and Somia Gul. Quim. Nova. Vol. 34, No. 4, 683-688,  2011.

22.     Simultaneous Determination of Sparfloxacin and Commonly Used H2 Receptor Antagonists by Rp-Hplc: Application to In-Vitro Drug Interactions, Najma Sultana, M. Saeed Arayne, Somia Gul*, Mahwish Akhtar and Sana Shamim, Medicinal Chemistry Research, published online 26th February, 2011.

23.    Simultaneous Determination of Gemifloxacin and Diuretics in Bulk, Pharmaceutical Dosage Forms and Human Serum By RP-HPLC, Najma Sultana, M. Saeed Arayne, Sana Shamim*, Mahwish Akhtar and Somia Gul. Quim. nova, vol. 33, No.  7, 1590 – 1593 2010, IF: 1.09

24.     High-Performance Liquid Chromatography Assay for Moxifloxacin in Bulk, Pharmaceutical Formulations and Serum: Application to In-Vitro Metal Interactions, Najma Sultana, M. Saeed Arayne, Mahwish Akhtar,* Sana Shamim, Somia Gul and Moona Mehboob Khan.  Journal of Chinese Chemical Society, 2010, 57, 708-717.

25.    Sparfloxacin-metal complexes as antifungal agents-Their synthesis, characterization and antimicrobial activities.  Najma Sultana, M. Saeed Arayne, Somia Gul* and Sana Shamim. Journal of molecular structure, Volume 975, Issues 1-3, 30 June 2010, Pages 285-291. IF: 1.55

26.    Optimization and simultaneous determination of gemifloxacin and Non steroidal anti inflammatory drugs in bulok pharmaceutical formulations and human serum by RP-HPLC and its applications, Internationa research Journal of Pharmacy and Pharmacology, Sana Shamim, Najma Sultana, M. Saeed Arayne, Mahwish Akhtar and Somia Gul, 2012, International Research Journal of Pharmacy and Pharmacology

Book Publication

• Book titled “Interaction of Azithromycin and Gemifloxacin, LAMBERT Academic Publishing, 2012

Others

Service Activity

1. Introduction to genomic technologies
    
2. Life, Health, and Radiation
    
3. SARS-CoV2 Protein Modeling and Drug Docking
    
4. Data Visualization with Python, Access Bioinformatics Databases with Bio-python
    
5. Work Smarter with Microsoft Powerpoint from Coursera under the Free License from the Higher Education Commission of Pakistan.
    
6. Hybrid Ph.D. level course (1 credit-hour) entitled “Introduction to Computational Biology and Bioinformatics.”, 2022-2023 by Dr. Reaz-ud-din from Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi.
    
7. Certified course on “Introduction to Cheminformatics and Medicinal Chemistry” from Udemy on November 20, 2022 (3.0 Cr.Hr).
    
8. Certified course on “Basics of Bioinformatics Research, from idea to article” from Udemy on November 15th, 2022. (3.5 Cr.Hr).
    
9. How to Develop an Effective Grant Application Workshop, Professional Development
    
10. Workshop on Internal Quality Auditing, Dow University of Health Sciences, June, 2014.
     
11. 1st e-learning Faculty development workshop on Moodle for teachers: THE ESSENTIAL, Dow International Medical College, Dow University of Health Sciences, 26th Feb, 2013

12. PAK-US workshop on Application Of Nanotechnology, HEJ Research Institute of Chemistry, 29-30th May, 2012.

13. Regional workshop on Chemical Laboratory and Safety, Research Institute of Chemistry, 5-6th June, 2012.

14. Plagiarism, Dow International Medical College, Dow University of Health Sciences,, 8th March, 2012.

15. Workshop on Research Grant Writing, Dow International Medical College, Dow University of Health Sciences, 11th Dec, 2011.

16. Seminar/Workshop on Real Time PCR, Research Institute of Pharmaceutical Sciences, University of Karachi, 2007.

Research Grants and Contracts.

PROJECT APPROVED: Approved Project from H.E.C under IPFP programme titled “Degradative studies of fluoroquinolones using UV-Visible spectrophotometer.”

Selected Professional Presentations

Abstract Publications

• RP-HPLC method development of gemifloxacin with diuretics in their active and formulation, in 3rd international conference on recent innovation in pharmaceutical sciences (ICRIPS) 13-14 march, 2019, Islamabad.
   
• Preparation, Characterization, Antibacterial and Antifungal Studies of Azithromycin with Acid salts” in the 2nd International Symposium Cum Training Course On Molecular Medicine and Drug Research (MMDR) held from JANUARY 12-15, 2009 at University of Karachi, Karachi, Pakistan organized by Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270 – Pakistan.
   
• Drug dispensing practices in different areas of Karachi, 16th annual Conference of Medical Microbiology and infectious diseases Society of Pakistan on February 22-23, 2019, SIUT Karachi, Pakistan.
   
• Synthesis, Characterization, Antibacterial and Antifungal Studies of Gemifloxacin-Metal Complexes, 1st International Conference on Recent Innovations in Pharmaceutical Sciences, 3-5th March, 2015.
   
• 2nd National Conference on Research in Pharmacy, 7th September, 2013.“Clinical Based Survey On Drug Dispensing Practices: A Reflection Of Current Scenario”, 1st National Conference on Pharmacy Profession- A success tool for health Care System, 2-3rd May, 2012
   
• “New Derivatives of Gemifloxacin with NSAIDs-Their Synthesis, Characterization, Antimicrobial and antifungal Activities.” First International Conference of Chemistry & its role in Science held from JANUARY 03-05, 2011 at Jinnah University for Women, organized by Department of Chemistry, Jinnah University for Women, Karachi-75270, Pakistan.
   
• “Validated Method for the Determination of Gemifloxacin in Bulk, Pharmaceutical Formulations and Human Serum by RP-HPLC; In-vitro Applications.” First International Conference of Chemistry & its role in Science held from JANUARY 03-05, 2011 at Jinnah University for Women, organized by Department of Chemistry, Jinnah University for Women, Karachi-75270, Pakistan.
   
• Synthesis, Characterization, Antibacterial and Antifungal Studies of Gemifloxacin-Metal Complexes, 1st International Conference on Recent Innovations in Pharmaceutical Sciences, 3-5th March, 2015.
   
• 2nd National Conference on Research in Pharmacy, 7th September, 2013.“Clinical Based Survey On Drug Dispensing Practices: A Reflection Of Current Scenario”, 1st National Conference on Pharmacy Profession- A success tool for health Care System, 2-3rd May, 2012
   
• “New Derivatives of Gemifloxacin with NSAIDs-Their Synthesis, Characterization, Antimicrobial and antifungal Activities.” First International Conference of Chemistry & its role in Science held from JANUARY 03-05, 2011 at Jinnah University for Women, organized by Department of Chemistry, Jinnah University for Women, Karachi-75270, Pakistan.
   
• “Validated Method for the Determination of Gemifloxacin in Bulk, Pharmaceutical Formulations and Human Serum by RP-HPLC; In-vitro Applications.” First International Conference of Chemistry & its role in Science held from JANUARY 03-05, 2011 at Jinnah University for Women, organized by Department of Chemistry, Jinnah University for Women, Karachi-75270, Pakistan.
   
• “Validated method for the simultaneous determination of gemifloxacin and H2- receptor antagonists in bulk, pharmaceutical formulations and human serum by RP-HPLC; In-vitro applications” First National Conference On Physical & Environmental Chemistry (PEC-2010)
   
• “Synthesis, Characterization, Antibacterial and Antifungal Studies of Azithromycin with NSAID’s.” in 19th national chemistry conference held on 27-29 April 2009 at University of Peshawar, Peshawar, Pakistan.
   
• “Synthesis Characterization anti-bacterial and antifungal activities of Azithromycin – metal complexes.”

• Fifth Pharmacognosy Conference 2010 on Current Challenges in Medicines and Therapy.

1.  “Comparative In- vitro Anti-bacterial activity of Fluoroquinolones & Macrolides”. Fifth Pharmacognosy Conference 2010 on Current Challenges in Medicines and Therapy.
    
2. Preparation, Characterization, Antibacterial and Antifungal Studies of Azithromycin with Acid salts” in the 2nd International Symposium Cum Training Course On Molecular Medicine and Drug Research (MMDR) held from JANUARY 12-15, 2009 at University of Karachi, Karachi, Pakistan organized by Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
    
3. “Synthesis Characterization anti-bacterial and antifungal studies of Azithromycin with metals” First national symposium on analytical, environmental & applied chemistry held from OCTOBER 24 ~ 25  2008, Department of Chemistry, Shah Abdul Latif University – Khairpur – Pakistan

Oral Presentations

1. Oral Presentation accepted entitled: “New Derivatives of Gemifloxacin with NSAIDs-Their Synthesis, Characterization, Antimicrobial and antifungal Activities.” First International Conference of Chemistry & its role in Science held from JANUARY 03-05, 2011 at Jinnah University for Women, organized by Department of Chemistry, Jinnah University for Women, Karachi-75270, Pakistan.
    
2. Oral Presentation accepted entitled: “Validated Method for the Determination of Gemifloxacin in Bulk, Pharmaceutical Formulations and Human Serum by RP-HPLC; In-vitro Applications.” First International Conference of Chemistry & its role in Science held from JANUARY 03-05, 2011 at Jinnah University for Women, organized by Department of Chemistry, Jinnah University for Women, Karachi-75270, Pakistan.
    
3.  Oral presentation entitled: “Validated method for the simultaneous determination of gemifloxacin and H2- receptor antagonists in bulk, pharmaceutical formulations and human serum by RP-HPLC; In-vitro applications” First National Conference On Physical & Environmental Chemistry (PEC-2010)
    
4. Oral presentation entitled: “Synthesis, Characterization, Antibacterial and Antifungal Studies of Azithromycin with NSAID’s.” in 19th national chemistry conference held on 27-29 April 2009 at University of Peshawar, Peshawar, Pakistan.

Poster Presentations

1. Poster Presentation accepted entitled: “Synthesis, Characterization and antimicrobial screening of Gemifloxacin Complexes with metals essential to human body”. First International Conference of Chemistry & its role in Science held from JANUARY 03-05, 2011 at Jinnah University for Women, organized by Department of Chemistry, Jinnah University for Women, Karachi-75270, Pakistan.
    
2. Poster Presentation accepted entitled: “Synthesis, Characterization and antimicrobial screening of Gemifloxacin Complexes with metals essential to human body”. First International Conference of Chemistry & its role in Science held from JANUARY 03-05, 2011 at Jinnah University for Women, organized by Department of Chemistry, Jinnah University for Women, Karachi-75270, Pakistan.
    
3. Poster Presentation entitled: “Synthesis Characterization anti-bacterial and antifungal activities of Azithromycin – metal complexes.” Fifth Pharmacognosy Conference 2010 on Current Challenges in Medicines and Therapy.
    
4. Poster Presentation entitled: “Comparative In- vitro Anti-bacterial activity of Fluoroquinolones & Macrolides”. Fifth Pharmacognosy Conference 2010 on Current Challenges in Medicines and Therapy.
    
5. Poster presentation entitled: “Preparation, Characterization, Antibacterial and Antifungal Studies of Azithromycin with Acid salts” in the 2nd International Symposium Cum Training Course On Molecular Medicine and Drug Research (MMDR) held from JANUARY 12-15, 2009 at University of Karachi, Karachi, Pakistan organized by Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
    
6. Poster Presentation entitled: “Synthesis Characterization anti-bacterial and antifungal studies of Azithromycin with metals” First national symposium on analytical, environmental & applied chemistry held from OCTOBER 24 ~ 25  2008, Department of Chemistry, Shah Abdul Latif University – Khairpur – Pakistan