Research Interest

Dr Mahwish Akhtar completed her PhD in Pharmaceutical Chemistry from the University of Karachi and was an Assistant Professor at Dow College of Pharmacy for 10 years. She was also awarded NRPU in 2016 and VCSF in 2019 as Co-PI. She received the SATHA Award for invention in 2017.

Research Publications

 BOOK PUBLICATIONS:
Mahwish Akhtar, Interaction of Moxifloxacin, LAMBERT Academic Publishing, 2012
ABSTRACT PUBLICATIONS:
1.    S Shamim, Mahwish Akhtar, S Shamim, Use of Magnetic Resonance Spectroscopy (MRS) as a Tool for Weight Reduction, 19 international Pharmacy Conference & Exhibition (IPCE 2016), PC hotel, Lahore, Pakistan, 21st -24th April 2016.  
2.    Mahwish Akhtar, N Sultana, MS Arayne, S Gul, S Shamim, Simultaneous Determination of Moxifloxacin with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) In Bulk, Dosage Formulations and Serum by RP-HPLC: Application to In-Vitro Drug Interactions, 3rd National Computational Sciences Conference (NCSC 2015), at Islamabad, May 13-15, 2015.
3.    S Shamim, N Sultana, MS Arayne, S Gul, Mahwish Akhtar, Synthesis, Characterization, Antibacterial and antifungal activities of Gemifloxacin-metal complexes, 1st International Conference on Recent Innovations in Pharmaceutical Sciences (ICRIPS-2015) at Islamabad, 3-5 March.
4.    Mahwish Akhtar, N Sultana, MS Arayne, S Gul, S Shamim, Simultaneous Determination of Moxifloxacin with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) In Bulk, Dosage Formulations and Serum by RP-HPLC: Application to In-Vitro Drug Interactions, Fourth Pre-Faculty Research Day Workshop, DUHS, 14 & 15 January, 2013
5.    S Shamim, Mahwish Akhtar, S Gul, Comparative In-Vitro Antibiotic Activity of Fluoroquinolones with Macrolides, Fourth Pre-Faculty Research Day Workshop, DUHS, 14 & 15 January, 2013
6.    Mahwish Akhtar, U Farwa, I Ali, S Hassan, H A Siddique, H Amin Sunshine vitamin deficiency despite abundant sun exposure, Golden Jubilee Cerebration theme: Post Graduate Medicinal Education of Physicians & surgeons Pakistan. 9th -11th Nov, 2012
7.    Mahwish Akhtar, U Farwa, I Ali, S Hassan, H A Siddique, H Amin, Sunshine vitamin deficiency despite abundant sun exposure, 1st National Conference on Pharmacy Profession, Dow University of Health Sciences, Karachi, Pakistan, 2nd  – 3rd  May, 2012
8.    S Gul, N Sultana, MS Arayne, S Shamim, Mahwish Akhtar, New Method for optimization and Simultaneous Determination of Sparfloxacin and Non Stroidal Anti inflammatory drugs: it’s invitro Application, 3rd Symposium on Pharmacist: Aneed of Health Care System, Karachi. 28th April 2012.
9.    Mahwish Akhtar, N Sultana and MS Arayne Simultaneous Determination of Moxifloxacin with NonSteroidal Anti-Inflammatory Drugs (NSAIDs) In Bulk, Dosage Formulations and Serum by RP-HPLC: Application to In-Vitro Drug Interactions. 3rd International Symposium cum Training Course on Molecular Medicine and Drug Research Karachi (MMDR) Karachi. 3-6 January, 2011.
10.    Mahwish Akhtar, N Sultana and MS Arayne Synthesis, Characterization and Antibacterial Studies of 1-cyclopropyl-7-[(s,s)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo3quinoline Carboxylic Acid with Antacids. 1st International Conference of Chemistry and its Role Science (ICCRS-1), Karachi. 3-5 January, 2011.
11.    Mahwish Akhtar, N Sultana and MS Arayne Simultaneous Determination of Moxifloxacin with NonSteroidal Anti-Inflammatory Drugs (NSAIDs) In Bulk, Dosage Formulations and Serum by RP-HPLC: Application to In-Vitro Drug Interactions. 1st International Conference of Chemistry and its Role Science (ICCRS-1), Karachi. 3-5 January, 2011.
12.    S Gul, S Shamim, Mahwish Akhtar, MM Khan and S Naveed Comparative in-vitro Antibacterial Activity of Fluoroquinolones and Macrolides. 5th Pharmacognosy Conference 2010 on Current Challenges in Medicine and Therapy. Karachi 10th July 2010.
13.    Mahwish Akhtar, N Sultana and MS Arayne Synthesis, Characterization and Antibacterial and Antifungal Studies of Moxifloxacin with NSAIDs. 19th National Chemistry Conference 2009, Kohat. June 9-11, 2009.
14.    Mahwish Akhtar, N Sultana and MS Arayne Synthesis, Characterization and Antibacterial Studies of Moxifloxacin with H2 Receptor Antagonists. 2nd International Symposium cum Training Course on Molecular Medicine and Drug Research Karachi, 12-15 January, 2009.
15.    Mahwish Akhtar, N Sultana and MS Arayne Synthesis, Characterization and Antibacterial Studies of 1-cyclopropyl-7-[(s,s)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo3quinoline Carboxylic Acid with Various Aromatic Amines. 1st National Symposium on Analytical, Environmental and Applied Chemistry, Khairpur. 24-25 October, 2008.
16.    N Sultana, MS Arayne and Mahwish Akhtar Synthesis, Characterization and Antibacterial Studies of 1-cyclopropyl-7-[(s,s)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo3quinoline carboxylic acid with Various Aliphatic and Aromatic Amines, Amides and Phenol. 17th International Conference on Organic Synthesis Daejeon, Korea. 22-27 June, 2008.
17.    N Sultana, MS Arayne and Mahwish Akhtar Synthesis, Characterization and Antibacterial Studies of 1-cyclopropyl-7-[(s,s)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo3quinoline Carboxylic Acid with Essential and Trace Elements. 18th National Chemistry Conference. Lahore. 25-27 February, 2008.
18.    N Sultana, MS Arayne and Mahwish Akhtar Synthesis, Characterization and Antibacterial Studies of 1-cyclopropyl-7-[(s,s)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo3quinoline carboxylic acid. 11th International Symposium on Natural Product Chemistry (11th ISNPC) Karachi, Pakistan. January 3-6, 2008.
PAPER PUBLICATIONS IN INTERNATIONAL JOURNALS
1.    N Sultana, MS Arayne, Mahwish Akhtar, S Shamim, S Gul and MM Khan (2010) High Performance Liquid Chromatography Assay for Moxifloxacin in Bulk, Pharmaceutical Formulations and Serum: Application to In-vitro Metal Interaction, Journal of the Chinese Chemical Society, 57, 708-717.
2.    N Sultana, S Shamim, Mahwish Akhtar, S Gul and MS Arayne (2010) Simultaneous determination of Gemifloxacin and diuretic in bulk, pharmaceutical formulation and human serum by RP-HPLC, Quimica Nova, 33, 1590-1593.
3.    N Sultana, Mahwish Akhtar, S Shamim, S Gul, and MS Arayne (2011) Simultaneous Determination of Moxifloxacin and H2 Receptor Antagonist In Pharmaceutical Dosage Formulations By RP-HPLC: Application To In-Vitro Drug Interactions, Quimica Nova, Vol. 34, 683-688
4.    N Sultana, MS Arayne, S Gul, Mahwish Akhtar and S Shamim (2011) Simultaneous Determination of Sparfloxacin and Commonly Used H2 Receptor Antagonists by Rp-HPLC: Application to In-Vitro Drug Interactions, Medicinal Chemistry Research, DOI10.1007/s00044-011-9586-4
5.    N Sultana, MS Arayne, S Shamim, Mahwish Akhtar and S Gul (2011) Validated Method for the Determination of Gemifloxacin in Bulk, Pharmaceutical Formulations and Human Serum by RP-HPLC; In-vitro Applications, Journal of the Brazilian Chemical Society, Vol. 22, 987-992
6.    S Gul, N Sultana, MS Arayne, S Shamim, and Mahwish Akhtar (2012) New Method for Optimization and Simultaneous Determination of Sparfloxacin and Non Steroidal Anti-Inflammatory Drugs: Its In-Vitro Application, American Journal of Analytical Chemistry, Vol. 3 (4), 328-337  DOI: 10.4236/ajac.2012.34045
7.    S Shamim, N Sultana, M S Arayne, Mahwish Akhtar and S Gul (2012) Optimization and simultaneous determination of gemifloxacin and Non-steroidal anti-inflammatory drugs in bulk, pharmaceutical formulations and human serum by RP-HPLC and its applications, International Research Journal of Pharmacy and Pharmacology (ISSN 2251-0176) Vol. 2(10)
8.    S Naveed, N Sultana, S M Arayne and Mahwish Akhtar (2013) In-vivo interaction studies of captopril with flurbiprofen and ibuprofen on carrageenan induced inflammation, Open Access Scientific Reports, Vol 2, (12), 1-3.
9.    S Gul, N Sultana, M. S Arayne, S Shamim, Mahwish Akhtar and A Khan (2013) Sparfloxacin-Metal Complexes as Urease Inhibitors: their Synthesis, Characterization, Antimicrobial and Anti-Enzymatic Evaluation, journal of chemistry, Vol 2013, 12.
10.    S Gul, N Sultana, M S Arayne, S Shamim, and Mahwish Akhtar (2013) Sparfloxacin Determination In Bulk Materials, Pharmaceutical Formulations and Human Serum by Reverse Phase HPLC Method, African Journal of pharmacy and Pharmacology, Vol 7 (30) 2131-2139.
11.    N sultana, M. S Arayne, Mahwish Akhtar (2014) Synthesis and Antimicrobial Chattels of 1-Cyclopropyl- 7-[(S,S)-2,8-Diazabicyclo [4.3.0]Non-8-Yl]-6-Fluoro-8- Methoxy-1,4-Dihydro-4-Oxo- 3-Quinolinecarboxylic Acid Metal Complexes of Biological Interest, JSM Chemistry, Vol 2(1) 1007.
12.    Rubina M., Sana S., Najma S., M. Saeed A. and Mahwish Akhtar, (2018) Rp-Hplc Method for The Simultaneous Estimation of Lisinopril and Diuretics In Bulk, Dosage Forms and Human Serum, IJBPAS, 7(12): 2005-2016
13.    Mahwish Akhtar, N Sultana, MS Arayne, TA Siddiqi, A Khan, (2019) Synthesis, characterization, antimicrobial and enzyme inhibitory studies of moxifloxacin with aromatic carboxylic acids, Pakistan Journal of Pharmaceutical Sciences, 32(3(suppl)): 1201-1206.
14.    Mahwish Akhtar, N Sultana, MS Arayne, TA Siddiqi, A Khan, (2019) Moxifloxacin-Ester derivatives: Synthesis, characterization and pharmacological evaluation, Pakistan Journal of Pharmaceutical Sciences, 32(3(special)): 1301-1306.
15.    Mahwish Akhtar, TA Siddiqi, S Inayat, S A Hassan, S Naz, (2019) Physicochemical, Pharmacokinetic and Toxicological Evaluation of 1-cyclopropyl-6-fluoroN'-isonicotinoyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carbohydrazide: An in-Silico Approach. IJBPAS, May, 2019, 8(5): 992-1002.
16.    Mahwish Akhtar, S Shamim, TA Siddiqi, N Sultana, MS Arayne, (2019) Synthesis and Antimicrobial Evaluation of Unique 3-Carboxamide Derivatives of Moxifloxacin with Selected H2 Inhibitor, IJBPAS, May, 2019, 8(5): 968-980.
17.    S Shamim, S Gul, Mahwish Akhtar, I Begum, H Ashraf (2021) synthesis, characterization, invitro bacterial, fungal and enzymatic activities of C-7 Modified Gemifloxacin Analogs, IJBPAS, June 2021 10(6): 1733-1745.
18.    Mahwish Akhtar, S Gul, S Shamim, (2021) Simultaneous Determination of Moxifloxacin with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) In Bulk, Dosage Formulations and Serum by RP-HPLC: Application to In-Vitro Drug Interactions, Pakistan Journal of Pharmaceutical Sciences 34 (6) 2091-2099.
19.    Mahwish Akhtar, S Shamim, (2021) Development of potent Remdesivir Derivative against SAR-CoV-2 protease inhibitors: Design, Modification, Molecular Modeling and Molecular Dynamics Simulations, Pakistan Journal of Pharmaceutical Sciences 34 (3) SUP.1119-1126.1.
20.    Zuneera Akram, Rehana Perveen, Saima Saleem, Mahwish Akhtar, Hina Abrar, Rubina Siddiqui, Muzammil Hussain, Usman Ghani Faqooqi, Shumaila Pervaiz, (2021)  In-Vitro and In Silico Antiplatelet Action of the New Piperidin4-One-Thiosemicarbazide Derivative, (Annals of R.S.C.B.), Vol. 25, Issue 6, 2021, pp. 20257 – 20266.
21.    Rubina Siddiqui, Shamim Akhtar, Shazia Haider, Zafar Saied Saify, Mahwish Akhtar and Sana Shamim, (2021) New series of hydrazinyl thiazole derivatives of piperidin-4-one:Synthesis, structural elucidation, analgesic activity and comparative structure activity relationship, Pak. J. Pharm. Sci., Vol.34, No.4, July 2021, pp.1415-1420.
22.    Mahwish Akhtar, NoorJahan, M Imran, Salman Asheaq Ahmed, Sara Naqvi, Syed Huzaifa Shah, Development of potent SARS-CoV 3CL protease inhibitors: in-silico Analogues Designing of Darunavir, Molecular Modelling and Molecular Dynamic Simulation, Asian Journal of Chemistry, Vol. 34 (9), 2343-2350.
23.    FM Khan, S Naeem, S Usmani, Mahwish Akhtar, S Akhtar, W Gul, Virtual Screening, Molecular Docking Study, Characterization, And In-Vitro Antibacterial Evaluation of Piperazine Derivatives, RADS Journal of Pharmacy and Pharmaceutical Sciences,  Vol 10 No 4 (2022). 

Others

Service Activity

1.    Preparing and delivering pharmaceutical chemistry (Theory) lectures.
2.    Designing and conducting the practical pharmaceutical chemistry (Lab)
3.    Invigilation of mid term paper and invigilation of terminal exam.
4.    Preparing lab manual.
5.    Taking viva examination.
6.    Making objectives of different courses assigned.
7.    Performing tasks as directed by Principal.

Brief Statement of Research Interest

•    Drug Interaction Studies
•    Computational Chemistry
•    Molecular docking and dynamics simulations 
•    Drug Designing
•    Analogues synthesis
•    Complexation with Metal Salts
•    Microbiological Assay
•    Method Development and Validation By HPLC.
•    Stability study

Honor and Awards

•    Qualified GAT-Test from NTS
•    Research Fellowship Award 2006-2008 
•    Drawing Competitions at School Level
•    Sports Participation at School Level

Research Grants and Contracts

•    Chrysin: A Promising Anticancer Agent its Designing, Synthesis of Analogs and Polymeric Drug loaded Nano-Particles and Activity Against Human Breast Cancer Cell (Project ID 15377) National Research Program for Universities (NRPU) HEC (work as a PI)
•    ANTITUBERCULAR ACTIVITY AND SAFETY EVALUATION OF VARIOUS SYNTHESIZED NEW DERIVATIVES OF FLUOROQUINOLONES (Project ID 3753) National Research Program for Universities (NRPU) HEC (work as a CoPI)
•    PHARMACODYNAMIC AND PHARMACOKINETIC STUDIES ON NOVEL SYNTHESISED COMPOUNDS AGAINST MDR-TB (VCSF) (work as a CoPI)
 

Other Research or Creative Accomplishments

 •     SATHA Award for invention 2017 (HPLC software for validation) 

Selected Professionals Presentations

1.    Oral presentation in 14th international symposium on natural product chemistry (ISNPC-14) HEJ research institute of chemistry. 6-8 November, 2018, Karachi Pakistan.
2.    Oral presentation in Innovative Technologies as part of 2nd Invention to innovation Summit Sindh-2017, Federal Urdu University for Art, Sciences and Technology. Karachi, Pakistan. 19th -21st December 2017. 
3.    Oral presentation in 28th National and 16th International chemistry conference: Global Challenges and Chemistry at Karachi, 20th -22nd November 2017
4.    Oral presentation in 3rd National Computational Sciences Conference (NCSC 2015), at Islamabad, May 13-15, 2015.
5.    Oral presentation in 1st International Conference of Chemistry and its Role Science (ICCRS-1), Jinnah University for Women, Karachi, Pakistan. 3-5th January 2011.