PRACTICE INTEGRATED CURRICULUM

Pharm. D curriculum is designed to produce scientifically and technically competent pharmacists who can employ their training and education in a manner so as to effectively provide quality healthcare services ultimately to the patient. The theory classes and the laboratory work are integrated and the hands-on training is enhanced by internships allowed after second year in pharmaceutical industries and in hospitals.

In addition, the research programs (M. Phil. and/or M.Phil. leading to Ph.D.) in Pharmacy Program at Dow College of Pharmacy have been designed not only to develop post graduates with sound knowledge of academics and research along with analytical and technical skills through provision of high quality learning and research environment in all fields of the pharmacy. Research students at DCOP is guided by a team of highly qualified HEC-approved supervisors, they are also provided facilities to work in advanced labs that will help in equipping the practicing pharmacists with the skills to progress into higher levels in all professions of pharmacy. This will enable them to meet the respective intra-disciplinary and cross-disciplinary challenges on the frontiers of pharmaceutical sciences.

CLINICAL WARD ROUNDS

During their study of courses, students are also provided with the opportunity to carry out clinical ward rounds under the supervision of experienced faculty members and healthcare professionals. This training enables the potential pharmacist to play a significant role in strengthening the quality of health care services in our society. Students of fourth and fifth professionals complete their training in Pharmaceutical service centers of Dow University Hospital and Civil Hospital (ambulatory dispensing area, emergency room pharmacy, in-patient pharmacy, out-patient pharmacy, bulk store, satellite pharmacy) and different wards (unit) like Medical ICU, Neonatal care unit, Cardiac care unit, cardiac ward, institute of chest diseases, Gynaecology ward, Neuro. / Psychiatry ward, Gastroenterology ward, Paediatric ward, Dialysis center. This clinical training is conducted at Dow University Hospital and Civil Hospital.

The main objectives of clinical training are:

• To provide student the opportunity to interact with patients and attending physicians, ask questions and observe how they care for patients in a real patient care setting.
• To improve their pharmacotherapeutic knowledge and professional competence in pharmacy practice
• To advance students’ communication skills for effective interaction with patients and other health professions.
• To enable future pharmacists to integrate the knowledge acquired in course work prior to clinical exposure, and to apply it to the practical scenarios, and to help students become more aware of the general methods of diagnosis and patient care specifically related to pharmacotherapeutics

Students are also offered different training programs like Basic Lifesaving Skills (BLS). 

INDUSTRIAL VISITS

To get industrial exposure during the study period, DCOP Students have visits of top national and multinational pharmaceutical companies of Pakistan. Students also have opportunity to avail internship programs and get experience of working in production, quality control, regulatory, marketing and R&D department in different pharmaceutical industries. These industrial exposures enable students to gain insight about industrial working environment and practices

DISCIPLINES OF STUDY

Pharmacy is an integral part of health care system. Pharmacy professionals ensure safe and effective use of drugs throughout the society whether in hospitals, clinics or community. Pharmacy aims to enhance public awareness for the appropriate use of medicinal substances and discourage misuse. Pharmacists also play vital roles in different areas of pharmaceutical industry including production, research and development, quality control, quality assurance, planning, warehouses, regulatory affairs, sales and marketing and many other capacities thereby leading to an improved overall performance and quality.

The Faculty of Pharmaceutical Sciences, Dow College of Pharmacy comprised of three capacious building having an area of 82500 sq.ft overall. Each building has fully air-conditioned spacious lecture halls equipped with multimedia, fully equipped laboratories including laboratory for Pharmaceutics, Pharmacology, Pharmaceutical Chemistry, Pharmacognosy, Industrial Pharmacy, Quality Management, Instrumentation, Anatomy, Physiology, Pathology, Microbiology, Physical Pharmacy, Pharmaceutical Preparation, Compounding and Dispensing and Pharmaceutical Biochemistry.

The academic activities at Faculty of Pharmaceutical Sciences, Dow College of Pharmacy are divided into five major disciplines:

• Pharmacology.
• Pharmaceutics.
• Pharmaceutical Chemistry.
• Pharmacognosy.
• Pharmacy Practice

PHARMACOLOGY

Pharmacology is the study concerned with all aspects of actions of drugs and other chemicals on living system. It explores the action of drugs, adverse effects, drug interaction, contraindications and their pharmacokinetics. It provides pre-clinical and clinical education in areas of Pharmacology, Therapeutics and Toxicology for undergraduate and post graduate students. Pharmacological research areas include Cardiovascular Pharmacology, Clinical Pharmacology, Molecular and Biochemical Pharmacology, Neurosciences and Inflammatory Pharmacology.

PHARMACEUTICS

Pharmaceutics is the science of drug manufacturing. It involves the processes from new chemical entity turning into a dosage form, modification into the existing formulation in order to enhance their safety and efficacy. This field encompasses the knowledge and guidelines for the manufacturing of formulation, facilities used for manufacturing and regulations for the pharmaceutical manufacturing and marketing.

PHARMACEUTICAL CHEMISTRY

Pharmaceutical Chemistry addresses chemical aspects of drug development, analytical procedures, important reactions involved in quantification and quality testing of drugs. Medicinal chemistry is the most important aspect of this branch of Pharmacy, along with the other courses which make the students aware and to handle various instruments to be used for the analytical purposes including pH meter, Conductivity meter, UV-Visible Spectrophotometer, HPLC, Mass Spectrophotometer, IR and NMR Spectrophotometer, etc.

PHARMACOGNOSY

Pharmacognosy focuses on natural sources of the drugs including plants, animals and minerals. This science includes study related to Procurement of drugs from said sources, effects of these drugs on animals as well as human subjects, drug profiles etc. It also covers the clinical aspects of herbal medicines with quality control, toxicity studies as well as herbal drug interactions. It also elaborates the industrial aspects that cover the cosmaceuticals, nutraceuticals and exploration of new herbal drugs

PHARMACY PRACTICE

Department of Pharmacy Practice was established in the year 2014 Dec. 22nd, as per the requirements set forth by the Pharmacy Council of Pakistan. The curriculum of pharmacy practice has a major focus on practicing clinical skills in the community, hospital and clinical pharmacy setups learned in the classroom. It is mandatory for student to attend Ward rounds in two different hospital settings i.e. civil hospital, Dow University hospital and OICD, OJHA Campus. Students conduct ward rounds under the supervision of teaching faculty and with the facilitation of doctors to develop an understanding of patient history taking, lab data interpretation and enable them to suggest clinical interventions (i.e. via dose calculations and adjustments, detection of ADRs and interactions, following standard treatment guidelines and evidence based medicines).

ELIGIBILITY OF CANDIDATE ELIGIBILITY CRITERIA 

• HSSC (Intermediate Science) Pre-Medical/ A-Level or 
  Equivalent, Min. 60% marks  or equivalent  duly  certified by IBCC
• Minimum passing marks in entry test shall be 25%  
• Candidate’s domicile certificate of Sindh.

NUMBER OF SEATS 

• SEAT DISTRIBUTION FOR PHARM.D COURSE AT DOW COLLEGE OF PHARMACY

• OPEN MERIT	60
  Self-Finance  (Morning)	40
  Self-Finance  (Evening)	50
  TOTAL	150

CATEGORIES OF SEATS 

A. Open Merit (merit cum choice) 
B. Self- Finance (Morning & Evening) 

A. OPEN MERIT (merit cum choice) 

• 60 (Sixty) seats have been reserved for Open Merit candidates with Karachi domicile who have studied Matric / ‘O’ Level AND Inter / A Level in Karachi. B. Self- Finance (Morning and Evening) [merit cum choice]

• 40 (Forty) seats for morning and 50 (Fifty) seats for evening are reserved for candidates, fulfilling the eligibility criteria of open merit to be selected on merit cum choice basis.

NOTE:

• Admissions will be offered on MERIT CUM CHOICE BASIS in both categories.

Yearly Plan

1^ST Professional Pharm-D

2^nd Professional Pharm-D

3^rd Professional Pharm-D

4^th Professional Pharm-D

5^th Professional Pharm-D

SEMESTER FIRST:

ENGLISH-A (FUNCTIONAL ENGLISH)                                                     Cr.Hr.02

ENG 300

Objectives:  Enhance language skills and develop critical thinking.

Course Contents:

• Basics of Grammar: Parts of speech and use of articles. Sentence structure, active and passive voice; Practice in unified sentence. Analysis of phrase, clause and sentence structure. Transitive and intransitive verbs, punctuation and spelling.
• Comprehension: Answers to questions on a given text.
• Discussion: General topics and every-day conversation (topics for discussion to be at the discretion of the teacher keeping in view the level of students).
• Listening: Improve listening skills by showing documentaries/films carefully selected by subject teacher.
• Translation skills: Urdu to English.
• Paragraph writing: Topics to be chosen at the discretion of the teacher.
• Presentation skills: Introduction & practice to improve presentation skills.

NOTE: Extensive reading is required for vocabulary building.

PHYSICAL PHARMACY- I [TH]

PD- 301                                                                                                                     Cr. Hrs.  03

1. PHARMACY ORIENTATION

Introduction and orientation to the profession of pharmacy in relation  to Hospital Pharmacy, Retail pharmacy, Industrial pharmacy, Forensic Pharmacy, Pharmaceutical education and research etc.              

2. ETHICS IN PHARMACY: Brief introduction of ethics for pharmacy profession.

3).        HISTORY OF PHARMACY:

A survey of the history of pharmacy through Ancient, Greek and Arab periods with special reference to contribution of Muslim scientists to Pharmacy and Allied sciences.

4).        LITERATURE OF PHARMACY:  Introduction to literature of pharmacy.  An introduction of various official books such as  Pharmacopoeia,  formularies, codices, abstracts etc.

5).        PHYSICOCHEMICAL PROCESSES

            a).  Precipitation: Processes of precipitation and its application in Pharmacy.

            b).  Crystallization: Types of crystals, Mechanism and methods of crystallization and its applications in pharmacy.

            c).  Distillation: Simple distillation, fractional distillation, steam distillation, vacuum distillation, destructive distillation and their applications in pharmacy.

            d).  Adsorption Techniques: Adsorption Techniques and processes of adsorption in detail.   

e). Miscellaneous Processes: Efflorescence, deliquescence, lyophillization, elutriation, exsiccation, ignition, sublimation, fusion, decantation, evaporation, vaporization, centrifugation, desiccation, levigation and tritruration.

6).        PHYSICO -CHEMICAL PRINCIPLES:

            a).  Solutions:  Introduction, types, concentration expression methods, ideal and real solution, colligative properties, their mathematical derivation and applications in pharmacy, molecular weight determination, Distribution co-efficient and its applications in pharmacy.

            b).  Solubilization: Solubility, factors affecting solubility, surfactants their properties and types. Micelles, their formulation and types.

            c).  Ionization: pH, pH indicator, pka buffers, buffer’s equation,  Isotonic solution and their applications in pharmacy.

RECOMMENDED BOOKS:  

1).  Martin, Physical Pharmacy, B.I Waverty Pvt, Dehli 4^th Ed. 1994.

2).  Cooper and Gunn’s Tutorial Pharmacy, CBS Publishers & Distributors, New Dehli, 1986.

3).  Bentley’s, Pharmaceutics, All India Traveler Book Seller, New Dehli 1996.

4).  Martin. P. Bustamante, P and Chun, Physical & Clinical Principal’s of Pharmaceutical Science, A.H.C  4^th Edition (1999), New York.

5).  Martin A. M. N, Banker G.S. and Chun A.H.C Advance in Pharmaceutical Sciences. Academic Press London. 1985.

6).  Mill C.C. Casson N. Rheology of disperse system, Pergamon Press, New Dehli, 1975.

7).  Rienger M and Scott-Blair. G. W Reology Academic Press London 1972.

8).  Barry B. W. Advances in Pharmaceutical Sciences, Academic Press, London. 1990.

9).  Sherman P. Emulsion Sciences. Academic Press, London 1972.

10). Martine A. Swarbrick J. and Cammatra A. Physical Pharmacy 3^rd Ed. Lee & Febiger,      Philadelphia. 1983.

11). Attwood D. and Florence A. T. Surfactant System. Chapman and I tall Ltd. London, 1982.

12). Remington’s Pharmaceutical Sciences, Mack Publisher Company USA, 2001.

PHYSICAL PHARMACY-I [LAB]

PD- 303                                                                                                          Cr. Hrs.  01

NOTE: Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities e.g. Determination of Emulsion systems; Determination of particle size; Density, Specific Volume, Weights and Volumes of Liquids; Preparation of Buffer solutions and isotonic solution; Determination of %age composition of solutions by Specific Gravity method.

PHARMACEUTICAL MATHEMATICS

COURSE # PD-305                                                                                     Cr. Hr. 03

1).   ALGEBRA:   

a).   Set and Functions:

Elementary concepts of sets. Concept of Function, Domain and Range of a Function. Different types of Functions. Graphical representation of a function some applications of Function.

b).  Solution of linear and Quadratic Equations. Equations reducible to Quadratic form Solution of  

        simultaneous Equation.

c).   Arithmetic, Geometric and Harmonic Progressions. Arithmetic, Geometric and Harmonic Means

d).  Permutations and combinations.

e).  Binomial Theorem: Simple application.

2).   TRIGONOMETRY:

        Measurement of angles in Radian and degree. Definition of circular functions. Derivation of

        circular function for simple cases.

3).   ANALYTICAL GEOMETRY;

        Coordinates of points in a plane. Distance between two points in a plane Locus, Equations of 

        Straight line, Equation of Parabola, Circle and Ellipse.

4).   DIFFERENTIAL CALCULUS:

        Concept of derivation Rule of Differentiation Examples on the evaluation of Derivations.

        Derivatives of Exponential and Logarithmic Functions, Partial Derivations Higher order

        Derivatives. Maxima & Minima points of Inflection.

Z5). INTEGRAL CALCULUS:

        Concept of integration. Rules of integrations. Integrations of Algebra and Trigonometric functions

        by using different techniques.

RECOMMENDED BOOKS:

1).   C. H. Edwards. Jr. and David E Penney, Calculus and Analytic Geometry. Prentice--Hall, Inc.

        A division of Simon & Schuster Englewood Gliffs, New Jersey 07632, USA. 1995.

2).   Ahmed, B. and Khan, M. Mathematics for Pharmacists, Arsalan paper Mart: Multan. 1993. 

PHARMACEUTICAL ORGANIC CHEMISTRY-I TH]

COURSE # PD-307                                                                         Cr. Hrs. 03

1).        (a). Introduction to Pharmaceutical Chemistry, classification &nomenclature of  Organic Pharmaceutical compounds.  

(b). BASIC CONCEPTS:   Conjugation, hyper conjugation, steric effect, inductive effect, mesomeric effect, hydrogen bonding. Theory of resonance. Effect of structure on   reactivity compound. Tautomerism of carbonyl compounds.

2).        NUCLEOPHILIC AND ELECTROPHILIC SUBSTITUTION REACTION IN  ALIPHATIC AND AROMATIC SYSTEM.

3).        ORIENTATION IN ELECTROPHILIC SUBSTITUTION REACTIONS ON  BENZENE RING.

4).        ORGANIC REACTION :    Baeyer –villiger oxidation: Diels Alder reaction, Grignard’s  reaction, Metal hydride reduction and Wolf Kishner reduction. Friedel craft’s reaction, Perkin reaction, Cannizzaro reaction, Wolf Kisher reduction.

5).        CARBONIUM ION REARRANGEMENTS & THEIR STABILITY:   

            Pinacolone, Wagner-Merrwein, Wolf, Hofmann and Beckmann rearrangements.

6).        CARBANIONS & THEIR STABILITY:    

            Condensation reaction (Aldol condensation, Favorskii rearrangement; Wittig reaction).

7).        Stereoisomerism, Optical isomerism, geometrical isomerism, Tautomerism of carbonyl compounds, resolution of racemic mixture & conformational analysis.

8).        General methods of preparations, Properties, identification test and Pharmaceutical application of the following classes & their analogs of alcohols, Phenols, ether, ketons,  aldehydes, carboxylic acids, esters, amines, aniline, amide, imide, lactams, lactones, diazonium salts.

PHARMACEUTICAL ORGANIC CHEMISTRY -I LAB]

COURSE # PD-309                                                                                     Cr. Hr 01      

1. GLP and Introduction to Pharmaceutical Organic Chemistry Lab
2. To lab safety identify the given compound Oxalic Acid
3. To identify the given compound: Benzoic Acid
4. To identify the given compound : Salicylic Acid
5. To identify the given compound : Resorcinol
6. To identify the given compound : Urea
7. To identify the given compound : Thiourea
8. To identify the given compound : Benzamide
9. To identify the given compound : Citric Acid
10. To identify the given compound : Glucose
11. To identify the given compound : Thymol.
12. To identify the given compound : Fructose
13. To identify the given compound : Sucrose
14. To identify the given compound : Sulphanilic acid
15. To identify the given compound : 1-Naphthol

PHARMACEUTICAL BIOCHEMISTRY-I [TH]

COURSE # PD-311                                                                                                 Cr. Hr. 03

1. General Introduction and Basic Biochemical Principles
   1. Role of pharmaceutical Biochemistry in the health Professional
   2. Nature of Biochemical reactions

2. Basic Chemistry of Biomolecules (Nature, Classification etc.) and their

      Metabolic fate (Anabolism and Catabolism)

1. 1. Carbohydrates:
      1. Chemistry
      2. Classification
      3. Reactions of Carbohydrates
      4. Optical activity
      5. Biological/Clinical and pharmaceutical importance of carbohydrates.
      6.    Introduction to metabolism
      7.    Brief introduction to the digestion and absorption of carbohydrates
      8.    Glycolysis
      9.    Pentose Phosphate Pathway
      10. Glycogenolysis
      11. Glycogenesis
      12. Gluconeogenesis
      13. Citric acid cycle
      14. Energetics of various metabolic processes

1. 2. Proteins and Amino acids:
      1. Chemistry
      2. Classification of proteins and amino acids
      3. Reactions of proteins and amino acids
      4. Organizational levels
      5. Macromolecular nature of proteins
      6. Biological/ Clinical and pharmaceutical importance of proteins and amino acids.
      7. Brief introduction to the digestion and absorption of proteins and amino       acids
      8. Metabolism of essential and non-essential amino acids
      9. Biosynthesis and catabolism of Haeme and porphyrin compounds.

1. 1. Vitamins:
      1. Chemistry
      2. Classification (Fat-soluble and water-soluble vitamins)
      3. Biological and pharmaceutical importance of vitamins.

1. 1. 4. Role of Vitamins:

Physiological role of Fat-soluble (A, D, E and K) and Water-soluble (Thiamin, Riboflavin, Pantothenic acid, Niacin, Pyridoxal phosphate, Biotin Folic acid. Cyanocobalamin - members of B-complex family - and Ascorbic acid), Coenzymes and their role in the regulation of metabolic processes.

1. 2. Bioenergetics:
      1. Principles of bioenergetics
      2. Electron transport chain and oxidative phosphorylation

PHARMACEUTICAL BIOCHEMISTRY-I [LAB]

COURSE # PD-313                                                                                     Cr. Hr. 01

1. To prepare 0.9% Nacl solution
2. Detection of carbohydrates by Barfoed’s test method
3. Detection of reducing sugar by Benedict’s test.
4. Iodine test for carbohydrate detection
5. Seliwanoff’s test.
6. Oligosaccharide detection by Molisch test method.
7. Analysis for the presence of carbohydrate by Picric acid Test.
8. Osazone test
9. Detection or identification of unknown protein by Biuret test method
10. Detection of protein through Ninhydrin test
11. Detection of hydroxy phenyl group in provided protein by Millions test
12. Detection of sulphur containing protein.
13. Precipitation of protein by heat and acetic acid method
14. Qualitative test for amino acids by Pauly’s method.
15. Determination of proteins by Sakaguchi Test.